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Nanostructured Poly-l-lactide and Polyglycerol Adipate Carriers for the Encapsulation of Usnic Acid: A Promising Approach for Hepatoprotection.
Brugnoli, Benedetta; Perna, Greta; Alfano, Sara; Piozzi, Antonella; Galantini, Luciano; Axioti, Eleni; Taresco, Vincenzo; Mariano, Alessia; Scotto d'Abusco, Anna; Vecchio Ciprioti, Stefano; Francolini, Iolanda.
Afiliação
  • Brugnoli B; Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
  • Perna G; Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
  • Alfano S; Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
  • Piozzi A; Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
  • Galantini L; Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
  • Axioti E; School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
  • Taresco V; School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
  • Mariano A; Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro, 5, 00185 Rome, Italy.
  • Scotto d'Abusco A; Department of Biochemical Sciences, Sapienza University of Rome, P.le A. Moro, 5, 00185 Rome, Italy.
  • Vecchio Ciprioti S; Department of Basic and Applied Science for Engineering, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy.
  • Francolini I; Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 00185 Rome, Italy.
Polymers (Basel) ; 16(3)2024 Feb 03.
Article em En | MEDLINE | ID: mdl-38337316
ABSTRACT
The present study investigates the utilization of nanoparticles based on poly-l-lactide (PLLA) and polyglycerol adipate (PGA), alone and blended, for the encapsulation of usnic acid (UA), a potent natural compound with various therapeutic properties including antimicrobial and anticancer activities. The development of these carriers offers an innovative approach to overcome the challenges associated with usnic acid's limited aqueous solubility, bioavailability, and hepatotoxicity. The nanosystems were characterized according to their physicochemical properties (among others, size, zeta potential, thermal properties), apparent aqueous solubility, and in vitro cytotoxicity. Interestingly, the nanocarrier obtained with the PLLA-PGA 50/50 weight ratio blend showed both the lowest size and the highest UA apparent solubility as well as the ability to decrease UA cytotoxicity towards human hepatocytes (HepG2 cells). This research opens new avenues for the effective utilization of these highly degradable and biocompatible PLLA-PGA blends as nanocarriers for reducing the cytotoxicity of usnic acid.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Polymers (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Polymers (Basel) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália