Simplified Version of the Eschweiler-Clarke Reaction.
J Org Chem
; 89(5): 3580-3584, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38362854
ABSTRACT
The traditional Eschweiler-Clarke reaction is a three-component process involving formaldehyde, amine, and formic acid. In this work, we showed that the reductive potential of formaldehyde was sufficient to provide methylation of secondary amines in the absence of acidic additives. Various acid-sensitive moieties remain intact under developed conditions. The scalability of the elaborated approach was shown for several products. Synthesis of the antifungal agent butenafine demonstrated the preparative utility of the developed approach.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
/
J. org. chem
/
Journal of organic chemistry
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Federação Russa