Your browser doesn't support javascript.
loading
Prediction of cervical lymph node metastasis in differentiated thyroid cancer based on radiomics models.
Mu, Jingshi; Cao, Yuan; Zhong, Xiao; Diao, Wei; Jia, Zhiyun.
Afiliação
  • Mu J; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Cao Y; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Zhong X; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Diao W; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Jia Z; Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Br J Radiol ; 97(1155): 526-534, 2024 Feb 28.
Article em En | MEDLINE | ID: mdl-38366237
ABSTRACT

OBJECTIVE:

The accurate clinical diagnosis of cervical lymph node metastasis plays an important role in the treatment of differentiated thyroid cancer (DTC). This study aimed to explore and summarize a more objective approach to detect cervical malignant lymph node metastasis of DTC via radiomics models.

METHODS:

PubMed, Web of Science, MEDLINE, EMBASE, and Cochrane databases were searched for all eligible studies. Articles using radiomics models based on ultrasound, computed tomography, or magnetic resonance imaging to assess cervical lymph node metastasis preoperatively were included. Characteristics and diagnostic accuracy measures were extracted. Bias and applicability judgments were evaluated by the revised QUADAS-2 tool. The estimates were pooled using a random-effects model. Additionally, the leave-one-out method was conducted to assess the heterogeneity.

RESULTS:

Twenty-nine radiomics studies with 6160 validation set patients were included in the qualitative analysis, and 11 studies with 3863 validation set patients were included in the meta-analysis. Four of them had an external independent validation set. The studies were heterogeneous, and a significant risk of bias was found in 29 studies. Meta-analysis showed that the pooled sensitivity and specificity for preoperative prediction of lymph node metastasis via US-based radiomics were 0.81 (95% CI, 0.73-0.86) and 0.87 (95% CI, 0.83-0.91), respectively.

CONCLUSIONS:

Although radiomics-based models for cervical lymphatic metastasis in DTC have been demonstrated to have moderate diagnostic capabilities, broader data, standardized radiomics features, robust feature selection, and model exploitation are still needed in the future. ADVANCES IN KNOWLEDGE The radiomics models showed great potential in detecting malignant lymph nodes in thyroid cancer.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide Limite: Female / Humans Idioma: En Revista: Br J Radiol / Br. j. radiol / British journal of radiology Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide Limite: Female / Humans Idioma: En Revista: Br J Radiol / Br. j. radiol / British journal of radiology Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China