Bioactive 5/5/5/6 Four-Ring System Iridoids from Plumeria alba L.
Chem Biodivers
; 21(4): e202400188, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38372184
ABSTRACT
Two rare 5/5/5/6 four-ring system iridoids, allamancinsâ
A and B (1 and 2) together with one known biogenetically related iridoid derivative, 3-O-methyallamancin (3) were isolated from the flowers of Plumeria alba L. The structures of these iridoid derivatives were determined by comprehensive spectroscopic analyses. The absolute configuration of 1 was confirmed by X-ray crystallographic analysis. The inhibitory activities of compoundsâ
1-3 against nitric oxide (NO) production induced and three cancer cell lines were evaluated inâ
vitro. Compoundsâ
1 and 3 showed inhibitory activities on NO production with IC50 values of 18.3±0.12 and 22.1±0.14â
µM, respectively. Compoundsâ
1-3 showed moderate inhibitory activities against cancer cell lines of A549, Hela and MCF-7.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apocynaceae
/
Iridoides
Limite:
Humans
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China