The prognosis of haploidentical hematopoietic stem cell transplantation in infants and patients under 3 years old with acute leukemia.
Clin Transplant
; 38(2): e15247, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-38375911
ABSTRACT
BACKGROUND:
The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients <3 years of age remains controversial. Data on haploidentical donor (HID) transplants in this age group is limited. PATIENTS ANDMETHODS:
We retrospectively analyzed the prognosis of 97 patients with acute leukemia aged <3 years who underwent HID transplantation at our institute.RESULTS:
With a median follow-up of 45 months, the 3-year disease-free survival (DFS), overall survival (OS), and 3-year cumulative incidence rate of treatment-related mortality were 69.3% (95% confidence interval (CI) 59.9%-78.7%), 74.2% (95% CI 65.2%-83.2%), and 3.6% (95% CI 0.9%-9.7%) in all 97 patients, respectively. The 3-year DFS and OS rate in patients diagnosed <1 year and patients diagnosed ≥1 year were comparable 77.8% (95% CI 62.2%-93.4%) versus 66.3% (95% CI 55.0%-77.6%, p = .253) and 82.5% (95% CI 66.3-98.7%) versus 72.8% (95% CI 61.9%-83.7%, p = .153), respectively. At the last follow-up, 23 patients had died, and 20 had died of relapse. Multivariate analysis revealed that positive pre-HSCT flow cytometric minimal residual disease (hazard ratio 5.605, p = .000) and AML-M7 expression (hazard ratio 2.906, p = .014) were independent adverse prognostic variables for relapse.CONCLUSIONS:
HID transplantation is potent and safe for infants and young patients with acute leukemia. Relapse is the primary cause of treatment failure.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Transplante de Células-Tronco Hematopoéticas
Limite:
Child, preschool
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Humans
Idioma:
En
Revista:
Clin Transplant
/
Clin. transplant
/
Clinical transplantation
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2024
Tipo de documento:
Article