Your browser doesn't support javascript.
loading
Prediction of the development of new coronary atherosclerotic plaques with radiomics.
Lee, Sang-Eun; Hong, Youngtaek; Hong, Jongsoo; Jung, Juyeong; Sung, Ji Min; Andreini, Daniele; Al-Mallah, Mouaz H; Budoff, Matthew J; Cademartiri, Filippo; Chinnaiyan, Kavitha; Choi, Jung Hyun; Chun, Eun Ju; Conte, Edoardo; Gottlieb, Ilan; Hadamitzky, Martin; Kim, Yong Jin; Lee, Byoung Kwon; Leipsic, Jonathon A; Maffei, Erica; Marques, Hugo; Gonçalves, Pedro de Araújo; Pontone, Gianluca; Shin, Sanghoon; Stone, Peter H; Samady, Habib; Virmani, Renu; Narula, Jagat; Shaw, Leslee J; Bax, Jeroen J; Lin, Fay Y; Min, James K; Chang, Hyuk-Jae.
Afiliação
  • Lee SE; Division of Cardiology, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea; CONNECT-AI Research Center, Yonsei University College of Medicine, Seoul, South Korea.
  • Hong Y; CONNECT-AI Research Center, Yonsei University College of Medicine, Seoul, South Korea.
  • Hong J; Division of Biostatistics, Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, South Korea.
  • Jung J; Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, South Korea.
  • Sung JM; CONNECT-AI Research Center, Yonsei University College of Medicine, Seoul, South Korea.
  • Andreini D; IRCCS Ospedale Galeazzi Sant'Ambrogio, Milan, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
  • Al-Mallah MH; Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TX, USA.
  • Budoff MJ; Department of Medicine, Lundquist Institute at Harbor-UCLA, Torrance, CA, USA.
  • Cademartiri F; Department of Radiology, Fondazione Monasterio, Pisa, Italy.
  • Chinnaiyan K; Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.
  • Choi JH; Pusan University Hospital, Busan, South Korea.
  • Chun EJ; Seoul National University Bundang Hospital, Seongnam, South Korea.
  • Conte E; Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Gottlieb I; Department of Radiology, Casa de Saude São Jose, Rio de Janeiro, Brazil.
  • Hadamitzky M; Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, Germany.
  • Kim YJ; Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.
  • Lee BK; Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Leipsic JA; Department of Medicine and Radiology, University of British Columbia, Vancouver, BC, Canada.
  • Maffei E; IRCCS SYNLAB SDN, Naples, Italy.
  • Marques H; UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal.
  • Gonçalves PA; UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisbon, Portugal.
  • Pontone G; Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical, Dental and Surgical Sciences, University of Milan, Milan, Italy.
  • Shin S; Division of Cardiology, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea.
  • Stone PH; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Samady H; Georgia Heart Institute, Northeast Georgia Health System, Gainesville, GA, USA.
  • Virmani R; Department of Pathology, CVPath Institute, Gaithersburg, MD, USA.
  • Narula J; University of Texas Health Houston, Houston, TX, USA.
  • Shaw LJ; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Bax JJ; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Lin FY; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Min JK; Cleerly, Inc, New York, NY, USA.
  • Chang HJ; CONNECT-AI Research Center, Yonsei University College of Medicine, Seoul, South Korea; Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul, South Korea. Electronic address: hjchang@yuhs.ac.
J Cardiovasc Comput Tomogr ; 18(3): 274-280, 2024.
Article em En | MEDLINE | ID: mdl-38378314
ABSTRACT

BACKGROUND:

Radiomics is expected to identify imaging features beyond the human eye. We investigated whether radiomics can identify coronary segments that will develop new atherosclerotic plaques on coronary computed tomography angiography (CCTA).

METHODS:

From a prospective multinational registry of patients with serial CCTA studies at ≥ 2-year intervals, segments without identifiable coronary plaque at baseline were selected and radiomic features were extracted. Cox models using clinical risk factors (Model 1), radiomic features (Model 2) and both clinical risk factors and radiomic features (Model 3) were constructed to predict the development of a coronary plaque, defined as total PV â€‹≥ â€‹1 â€‹mm3, at follow-up CCTA in each segment.

RESULTS:

In total, 9583 normal coronary segments were identified from 1162 patients (60.3 â€‹± â€‹9.2 years, 55.7% male) and divided 82 into training and test sets. At follow-up CCTA, 9.8% of the segments developed new coronary plaque. The predictive power of Models 1 and 2 was not different in both the training and test sets (C-index [95% confidence interval (CI)] of Model 1 vs. Model 2 0.701 [0.690-0.712] vs. 0.699 [0.0.688-0.710] and 0.696 [0.671-0.725] vs. 0.0.691 [0.667-0.715], respectively, all p â€‹> â€‹0.05). The addition of radiomic features to clinical risk factors improved the predictive power of the Cox model in both the training and test sets (C-index [95% CI] of Model 3 0.772 [0.762-0.781] and 0.767 [0.751-0.787], respectively, all p â€‹< â€‹00.0001 compared to Models 1 and 2).

CONCLUSION:

Radiomic features can improve the identification of segments that would develop new coronary atherosclerotic plaque. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov NCT0280341.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Sistema de Registros / Valor Preditivo dos Testes / Angiografia Coronária / Vasos Coronários / Placa Aterosclerótica / Angiografia por Tomografia Computadorizada Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiovasc Comput Tomogr Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Sistema de Registros / Valor Preditivo dos Testes / Angiografia Coronária / Vasos Coronários / Placa Aterosclerótica / Angiografia por Tomografia Computadorizada Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Cardiovasc Comput Tomogr Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / RADIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Coréia do Sul