An Automated Visual Psychophysics Method to Measure Visual Function in Swine Preclinical Animal Model.
Transl Vis Sci Technol
; 13(3): 8, 2024 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-38470318
ABSTRACT
Purpose:
The aim of this study was to develop and validate a test to assess visual function in pigs using the visual psychophysics contrast sensitivity function.Methods:
We utilized a touchscreen along with a pellet reward dispenser to train three Göttingen pigs on a visual psychophysics test and determined their contrast sensitivity function. Images with different contrast resolutions were used as visual stimuli and presented against a control image in a two-choice test. Following animals' acclimatization and the first phase of training, the system was arranged such that animals could self-run multiple consecutive trials without human intervention.Results:
All animals were trained within a week and remembered the task with 1 day of reinforcement when tested 1 month after the last visual assessment. All trained animals performed well during the trial with minimal screen side bias, especially at contrast threshold above 40%.Conclusions:
Göttingen pigs are trainable for a visual psychophysics test and able to self-run the trial without human intervention. Translational Relevance Contrast sensitivity is one of the key parameters to assess visual function in humans. The possibility of measuring the same parameters in a large animal model allows for a better translation and understanding of drug safety and efficacy in preclinical ophthalmology.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oftalmologia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Transl Vis Sci Technol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos