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Association of sodium-glucose cotransporter-2 inhibitors and the risk of retinal vascular occlusion: A real-world retrospective cohort study in Taiwan.
Lin, Tzu-Yi; Kang, Eugene Yu-Chuan; Shao, Shih-Chieh; Lai, Edward Chia-Cheng; Wang, Nan-Kai; Garg, Sunir J; Chen, Kuan-Jen; Kang, Je-Ho; Wu, Wei-Chi; Lai, Chi-Chun; Hwang, Yih-Shiou.
Afiliação
  • Lin TY; Department of Education, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
  • Kang EY; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Shao SC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Lai EC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
  • Wang NK; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Garg SJ; Department of Pharmacy, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
  • Chen KJ; School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Kang JH; School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Wu WC; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
  • Lai CC; Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, USA.
  • Hwang YS; Mid Atlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Diabetes Metab Res Rev ; 40(2): e3773, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38598767
ABSTRACT

AIMS:

Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are proposed to alleviate the development of inflammatory eye diseases. However, the association between SGLT2i and retinal vascular occlusion remains unclear. Therefore, this study aims to explore the effects of SGLT2i on the incidence of retinal vascular occlusion. MATERIALS AND

METHODS:

This retrospective cohort study analysed electronic medical records data from the largest multi-institutional database in Taiwan. Individuals who initiated SGLT2is and dipeptidyl peptidase 4 inhibitors (DPP4is) between 2016 and 2019 were included in our analysis. To conduct a homogenous comparison, inverse probability of treatment weighting with propensity scoring was employed. The primary outcome was retinal vascular occlusion, and the secondary outcomes were retinal vascular occlusion-related complications (macular oedema, vitreous haemorrhage, and tractional retinal detachment) and conditions requiring vitreoretinal intervention (intravitreal injection, retinal laser therapy, and vitrectomy).

RESULTS:

In total, 12,074 SGLT2i users and 39,318 DPP4i users were included. The incidence rate of retinal vascular occlusion in the SGLT2i and DPP4i groups was 1.2 (95% confidence interval [CI], 0.9-1.4) and 1.6 (95% CI, 1.3-1.8) events per 1000 person-years, respectively, which yielded a subdistribution hazard ratio (SHR) of 0.74 (95% CI, 0.55-0.99). Similar risk reductions were observed in the retinal vascular occlusion-related complications (SHR, 0.76; 95% CI, 0.69-0.84) and conditions requiring vitreoretinal intervention (SHR, 0.84; 95% CI, 0.77-0.94).

CONCLUSIONS:

In this multi-institutional study in Taiwan, SGLT2i use was associated with a reduced risk of retinal vascular occlusion. Further prospective studies are required to ascertain this association.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Dipeptidil Peptidase IV / Inibidores do Transportador 2 de Sódio-Glicose Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Diabetes Metab Res Rev Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores da Dipeptidil Peptidase IV / Inibidores do Transportador 2 de Sódio-Glicose Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Diabetes Metab Res Rev Assunto da revista: ENDOCRINOLOGIA / METABOLISMO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Taiwan