Does Eta Protein Differentiate Rheumatoid Arthritis from Psoriatic Arthritis?
Curr Med Chem
; 31(39): 6510-6520, 2024.
Article
em En
| MEDLINE
| ID: mdl-38685775
ABSTRACT
AIM:
The clinical symptoms and laboratory markers of Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) can be very similar, so making a differential diagnosis between these two diseases is often difficult. Serological parameters to be used in differential diagnosis can guide the clinician. This study aimed to investigate the usability of 14-3-3η (eta) protein as a biomarker in the differential diagnosis of PsA and RA, and the relationships between eta protein and disease activity scores and joint erosions in PsA and RA.METHODS:
54 PsA patients, 53 RA patients, and 56 healthy individuals were included in this study. The ELISA (Enzyme-Linked ImunoSorbent Assay) kit was used as a quantitative sandwich enzyme immunoassay technique to detect human eta protein levels. Receiver- operating Characteristic (ROC) curves analysis was used to determine the sensitivity and specificity of the eta protein.RESULTS:
Eta protein levels were found to be significantly higher in the RA group than in the PsA [B -0.341, OR (95% CI) 0.711 (0.556-0.909), p 0.007] and control [B -0.225, OR (95% CI) 0.798 (0.641-0.995), p 0.045] groups. Eta protein median values were significantly higher in patients with joint erosion than in those without [ß= 0.151, OR (95% CI) 1.163 (1.003-1.349), p 0.046].CONCLUSION:
Eta protein levels are higher in the serum of RA patients than PsA and are associated with joint erosion. Eta protein may be a potential biomarker in the differential diagnosis of RA and PsA. It may represent a possible therapeutic step in the pathophysiological pathways in the development of joint erosion.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Biomarcadores
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Artrite Psoriásica
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Proteínas 14-3-3
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Curr Med Chem
/
Curr. med. chem
/
Current medicinal chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Turquia