Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
Nat Metab
; 6(5): 963-979, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38693320
ABSTRACT
Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
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Caracteres Sexuais
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Gordura Subcutânea
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Tecido Adiposo Branco
Limite:
Animals
Idioma:
En
Revista:
Nat Metab
/
Nat. metab
/
Nature metabolism
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos