Meta-analysis identifying gut microbial biomarkers of Qinghai-Tibet Plateau populations and the functionality of microbiota-derived butyrate in high-altitude adaptation.
Gut Microbes
; 16(1): 2350151, 2024.
Article
em En
| MEDLINE
| ID: mdl-38715346
ABSTRACT
The extreme environmental conditions of a plateau seriously threaten human health. The relationship between gut microbiota and human health at high altitudes has been extensively investigated. However, no universal gut microbiota biomarkers have been identified in the plateau population, limiting research into gut microbiota and high-altitude adaptation. 668 16s rRNA samples were analyzed using meta-analysis to reduce batch effects and uncover microbiota biomarkers in the plateau population. Furthermore, the robustness of these biomarkers was validated. Mendelian randomization (MR) results indicated that Tibetan gut microbiota may mediate a reduced erythropoietic response. Functional analysis and qPCR revealed that butyrate may be a functional metabolite in high-altitude adaptation. A high-altitude rat model showed that butyrate reduced intestinal damage caused by high altitudes. According to cell experiments, butyrate may downregulate hypoxia-inducible factor-1α (HIF-1α) expression and blunt cellular responses to hypoxic stress. Our research found universally applicable biomarkers and investigated their potential roles in promoting human health at high altitudes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Butiratos
/
Biomarcadores
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Altitude
/
Microbioma Gastrointestinal
Limite:
Animals
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Gut Microbes
/
Gut microbes
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China