Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.
Trends Biochem Sci
; 49(8): 681-692, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38729842
ABSTRACT
Decades of work in developmental genetics has given us a deep mechanistic understanding of the fundamental signaling pathways underlying animal development. However, little is known about how these pathways emerged and changed over evolutionary time. Here, we review our current understanding of the evolutionary emergence of the Hippo pathway, a conserved signaling pathway that regulates tissue size in animals. This pathway has deep evolutionary roots, emerging piece by piece in the unicellular ancestors of animals, with a complete core pathway predating the origin of animals. Recent functional studies in close unicellular relatives of animals and early-branching animals suggest an ancestral function of the Hippo pathway in cytoskeletal regulation, which was subsequently co-opted to regulate proliferation and animal tissue size.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Proteínas Serina-Treonina Quinases
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2024
Tipo de documento:
Article