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HLA-C*07 is associated with symptomatic HIV-1-associated neurocognitive disorders (HAND) and immune dysregulation.
Pons-Fuster, Eduardo; Bernal, Enrique; Guillamón, Concepción F; Gimeno, Lourdes; Martínez-Sánchez, María V; Ruiz-Lorente, Inmaculada; Campillo, José A; Ceballos, Diana; Torres, Ana; Tomás, Cristina; Muñoz, Ángeles; Alcaraz, Antonia; Selma, Pedro; Ruiz-Nicolas, Carlos; Muro, Manuel; Minguela, Alfredo.
Afiliação
  • Pons-Fuster E; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Bernal E; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Guillamón CF; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Gimeno L; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Martínez-Sánchez MV; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Ruiz-Lorente I; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Campillo JA; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Ceballos D; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Torres A; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Tomás C; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Muñoz Á; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Alcaraz A; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Selma P; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Ruiz-Nicolas C; Infectious Disease Unit, University Hospital Reina Sofía and Murcia University and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Muro M; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
  • Minguela A; Immunologyservice, Clinic University Hospital Virgen de la Arrixaca and Biomedical Research Institute of Murcia Pascual Parrilla (IMIB), Murcia, Spain.
Infect Dis (Lond) ; : 1-12, 2024 May 14.
Article em En | MEDLINE | ID: mdl-38743055
ABSTRACT

BACKGROUND:

HIV-1-associated neurocognitive disorders (HAND) in stable patients undergoing antiretroviral therapy (ART) may result from ongoing immune dysregulation and chronic inflammation. A contributing factor may result from the unstable HLA class I allele, HLA-C*07.

OBJECTIVE:

To assess the genetic profile of killer-cell immunoglobulin-like receptors (KIR), human leukocyte antigens (HLA), and immune activation or senescence markers and their association with HAND in stable HIV-1 patients receiving ART.

METHODS:

An observational cross-sectional study was carried out with 96 patients with asymptomatic or symptomatic HAND. HLA and KIR as well as immune activation/senescence biomarkers in peripheral blood cells were assessed by SSO-Luminex typing and flow cytometry, respectively.

RESULTS:

HLA-C*07 is associated with symptomatic HAND. The frequency of two copies of HLA-C*07 was higher in patients with symptomatic than with asymptomatic HAND (12.0 vs. 2.2%, ρ < 0.001). The percentage of senescent CD8+CD28- T-cells was higher in patients with two copies of HLA-C*07 (ρ < 0.05). In patients with symptomatic HAND, the percentages of non-senescent CD8+CD28+ T cells were inversely proportional to the number of copies of the HLA-C*07 (ρ < 0.05).

CONCLUSION:

Patients with symptomatic HAND showed a higher frequency of the homozygotic unstable HLA-C*07 allotype, which could be associated with neurocognitive complications. Two copies of HLA-C*07 were associated with immune senescent T lymphocyte profiles characterized by the loss of CD28 expression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Infect Dis (Lond) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Infect Dis (Lond) Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Espanha