The Role of Beta2-Microglobulin in Central Nervous System Disease.
Cell Mol Neurobiol
; 44(1): 46, 2024 May 14.
Article
em En
| MEDLINE
| ID: mdl-38743119
ABSTRACT
Central nervous system (CNS) disorders represent the leading cause of disability and the second leading cause of death worldwide, and impose a substantial economic burden on society. In recent years, emerging evidence has found that beta2 -microglobulin (B2M), a subunit of major histocompatibility complex class I (MHC-I) molecules, plays a crucial role in the development and progression in certain CNS diseases. On the one hand, intracellular B2M was abnormally upregulated in brain tumors and regulated tumor microenvironments and progression. On the other hand, soluble B2M was also elevated and involved in pathological stages in CNS diseases. Targeted B2M therapy has shown promising outcomes in specific CNS diseases. In this review, we provide a comprehensive summary and discussion of recent advances in understanding the pathological processes involving B2M in CNS diseases (e.g., Alzheimer's disease, aging, stroke, HIV-related dementia, glioma, and primary central nervous system lymphoma).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Sistema Nervoso Central
/
Microglobulina beta-2
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Neurobiol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China