Intranasal vitamin B12 administration in elderly patients: A randomized controlled comparison of two dosage regimens.
Br J Clin Pharmacol
; 90(8): 1975-1983, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38747399
ABSTRACT
AIM:
Vitamin B12 deficiency is common in the elderly population. Standard treatment via intramuscular injections, however, has several disadvantages. Safer and more convenient dosage forms such as intranasal are therefore being explored. This study compares the effects of two intranasal vitamin B12 dosage regimens in elderly vitamin B12-deficient patients.METHODS:
Sixty patients ≥65 years were randomly assigned to either a loading dose (daily administration for 14 days followed by weekly administration) or a no loading dose (administration every 3 days) regimen for 90 days. Each dose contained 1000 µg cobalamin. Total vitamin B12, holotranscoblamin (holoTC), methylmalonic acid (MMA) and total homocysteine (tHcy) levels in serum were measured on days 0, 7, 14, 30, 60 and 90.RESULTS:
Both dosage regimens resulted in a rapid increase of vitamin B12 and holoTC concentrations and normalization of initial high, MMA and tHcy concentrations. The loading dose regimen resulted in the fastest and greatest increase to a median vitamin B12 of 1090 pmol/L (reference 350-650 pmol/L) concentration after 14 days. Following weekly administration, B12 rapidly decreased to a median concentration of 530 pmol/L after 90 days. The no loading dose regimen resulted in a steady increase to a median vitamin B12 of 717 pmol/L after 90 days.CONCLUSIONS:
Intranasal vitamin B12 administration is an effective and suitable way to replenish and sustain vitamin B12 levels in elderly patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Deficiência de Vitamina B 12
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Administração Intranasal
Limite:
Aged
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Aged80
/
Female
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Humans
/
Male
Idioma:
En
Revista:
Br J Clin Pharmacol
/
Br. j. clin. pharmacol
/
British journal of clinical pharmacology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Holanda