Development of neonatal connectome dynamics and its prediction for cognitive and language outcomes at age 2.
Cereb Cortex
; 34(5)2024 May 02.
Article
em En
| MEDLINE
| ID: mdl-38771241
ABSTRACT
The functional brain connectome is highly dynamic over time. However, how brain connectome dynamics evolves during the third trimester of pregnancy and is associated with later cognitive growth remains unknown. Here, we use resting-state functional Magnetic Resonance Imaging (MRI) data from 39 newborns aged 32 to 42 postmenstrual weeks to investigate the maturation process of connectome dynamics and its role in predicting neurocognitive outcomes at 2 years of age. Neonatal brain dynamics is assessed using a multilayer network model. Network dynamics decreases globally but increases in both modularity and diversity with development. Regionally, module switching decreases with development primarily in the lateral precentral gyrus, medial temporal lobe, and subcortical areas, with a higher growth rate in primary regions than in association regions. Support vector regression reveals that neonatal connectome dynamics is predictive of individual cognitive and language abilities at 2 years of age. Our findings highlight network-level neural substrates underlying early cognitive development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Imageamento por Ressonância Magnética
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Cognição
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Conectoma
Limite:
Child, preschool
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Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Cereb Cortex
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Cereb. cortex
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Cerebral cortex
Assunto da revista:
CEREBRO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China