Your browser doesn't support javascript.
loading
Evaluation of the Quality of Life and the Demographic and Clinical Characteristics of Patients With Pemphigus With Oral Mucosal Involvement: A Multicenter Observational Study.
Polat, Asude Kara; Mülayim, Mehmet Kamil; Gür, Tugba Falay; Acar, Ayda; Bozca, Burçin Cansu; Ceylan, Can; Kilinç, Fadime; Güner, Rukiye Yasak; Albayrak, Hülya; Durdu, Murat; Aksu, Ayse Esra Koku; Nalbant, Fatma; Savk, Ekin; Bayramgürler, Dilek; Daye, Munise; Singer, Ralfi; Alatas, Emine Tugba; Erdemir, Vefa Asli; Gürel, Mehmet Salih; Uzun, Soner; Yayli, Savas.
Afiliação
  • Polat AK; Memorial Bahçelievler Hospital, Department of Dermatology, Istanbul, Turkey.
  • Mülayim MK; Kahramanmaras Sütçü Imam University Faculty of Medicine, Department of Dermatology, Kahramanmaras, Turkey.
  • Gür TF; University of Health Sciences, Sultan Abdulhamid Han Training and Research Hospital, Department of Dermatology, Istanbul, Turkey.
  • Acar A; Ege University Faculty of Medicine, Department of Dermatology, Izmir, Turkey.
  • Bozca BC; Akdeniz University, Faculty of Medicine, Department of Dermatology, Antalya, Turkey.
  • Ceylan C; Ege University Faculty of Medicine, Department of Dermatology, Izmir, Turkey.
  • Kilinç F; Ankara City Hospital, Department of Dermatology, Ankara, Turkey.
  • Güner RY; Sivas Cumhuriyet University, Faculty of Medicine, Department of Dermatology, Sivas, Turkey.
  • Albayrak H; Namik Kemal University Faculty of Medicine, Department of Dermatology, Tekirdag, Turkey.
  • Durdu M; Baskent University Adana Dr. Turgut Noyan Application and Research Center, Department of Dermatology, Adana, Turkey.
  • Aksu AEK; University of Health Sciences, Istanbul Training and Research Hospital, Department of Dermatology, Istanbul, Turkey.
  • Nalbant F; Edirne Kesan State Hospital, Department of Dermatology, Edirne, Turkey.
  • Savk E; Aydin Adnan Menderes University Faculty of Medicine, Department of Dermatology, Aydin, Turkey.
  • Bayramgürler D; Kocaeli University Faculty of Medicine, Department of Dermatology, Kocaeli, Turkey.
  • Daye M; Necmettin Erbakan University Meram Faculty of Medicine, Department of Dermatology, Konya, Turkey.
  • Singer R; Prof. Dr. Cemil Tascioglu City Hospital, Department of Dermatology, Istanbul, Turkey.
  • Alatas ET; Mugla Sitki Koçman University Faculty of Medicine, Faculty of Medicine, Department of Dermatology, Mugla, Turkey.
  • Erdemir VA; Medeniyet University Faculty of Medicine, Department of Dermatology, Istanbul, Turkey.
  • Gürel MS; Medeniyet University Faculty of Medicine, Department of Dermatology, Istanbul, Turkey.
  • Uzun S; Akdeniz University, Faculty of Medicine, Department of Dermatology, Antalya, Turkey.
  • Yayli S; Koç University Faculty of Medicine, Department of Dermatology, Istanbul, Turkey.
Dermatol Pract Concept ; 14(2)2024 Apr 01.
Article em En | MEDLINE | ID: mdl-38810063
ABSTRACT

INTRODUCTION:

Pemphigus vulgaris (PV) is an autoimmune disease primarily affecting the oral mucosa.

OBJECTIVES:

This study aimed to determine the demographic, clinical and treatment characteristics of PV patients with oral mucosal involvement and to assess the impact on their quality of life.

METHODS:

We conducted a prospective observational study among 106 patients diagnosed with PV and presenting oral mucosal involvement. Demographic data, clinical and treatment characteristics, and quality of life questionnaires were recorded.

RESULTS:

The study included 106 patients, 55 (51.89%) were male and there was a predominance of the mucocutaneous subtype in 83 individuals (78.38%). Oral mucosa was the initial site of manifestation in 44 patients (41.51%). Bilateral buccal mucosa was the most frequently affected site. The predominant symptom reported was a burning sensation, noted in 91 patients (85.85%). Oral mucosal examination revealed erosions in 85.85% of the patients. Systemic steroids were the most commonly administered treatment, and rituximab was used in 18 patients (16.98%). A positive and significant correlation was found between pemphigus severity and Oral Health Impact Profile-14, Dermatology Life Quality Index and Dermatological Quality of Life Scale scores (P < 0.05). The presence of superficial ulcers, flaccid bullae, lesion diameter ≥1 cm, and >10 lesions were factors that markedly diminished quality of life. Complete response to treatment was noted in all patients administered rituximab.

CONCLUSIONS:

The most common area of involvement was bilateral buccal mucosa, and the severity of PV closely correlated with a decline in quality of life measures. These results highlight the need for careful clinical oversight of PV, taking into account its effects on patients quality of life.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Dermatol Pract Concept Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Dermatol Pract Concept Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Turquia