Gene-environment interactions within a precision environmental health framework.
Cell Genom
; 4(7): 100591, 2024 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-38925123
ABSTRACT
Understanding the complex interplay of genetic and environmental factors in disease etiology and the role of gene-environment interactions (GEIs) across human development stages is important. We review the state of GEI research, including challenges in measuring environmental factors and advantages of GEI analysis in understanding disease mechanisms. We discuss the evolution of GEI studies from candidate gene-environment studies to genome-wide interaction studies (GWISs) and the role of multi-omics in mediating GEI effects. We review advancements in GEI analysis methods and the importance of large-scale datasets. We also address the translation of GEI findings into precision environmental health (PEH), showcasing real-world applications in healthcare and disease prevention. Additionally, we highlight societal considerations in GEI research, including environmental justice, the return of results to participants, and data privacy. Overall, we underscore the significance of GEI for disease prediction and prevention and advocate for integrating the exposome into PEH omics studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saúde Ambiental
/
Medicina de Precisão
/
Interação Gene-Ambiente
Limite:
Humans
Idioma:
En
Revista:
Cell Genom
/
Cell genomics
Ano de publicação:
2024
Tipo de documento:
Article