Androgen receptor post-translational modifications and their implications for pathology.
Biochem Soc Trans
; 52(4): 1673-1694, 2024 08 28.
Article
em En
| MEDLINE
| ID: mdl-38958586
ABSTRACT
A major mechanism to modulate the biological activities of the androgen receptor (AR) involves a growing number of post-translational modifications (PTMs). In this review we summarise the current knowledge on the structural and functional impact of PTMs that affect this major transcription factor. Next, we discuss the cross-talk between these different PTMs and the presence of clusters of modified residues in the AR protein. Finally, we discuss the implications of these covalent modifications for the aetiology of diseases such as spinal and bulbar muscular atrophy (Kennedy's disease) and prostate cancer, and the perspectives for pharmacological intervention.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Receptores Androgênicos
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Processamento de Proteína Pós-Traducional
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Biochem Soc Trans
/
Biochem. Soc. Trans
/
Biochemical society transactions
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha