A Plasmodium falciparum antigen that binds to host erythrocytes and merozoites.
Science
; 230(4725): 553-6, 1985 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-3901257
ABSTRACT
Antigens that bind to erythrocytes were identified in the supernatant fluids of a cultured human malaria parasite (Plasmodium falciparum). A 175-kilodalton (175K) antigen bound only to erythrocytes susceptible to invasion. The 175K antigen from the Camp or the FCR-3 strain also bound to merozoites. However, the antigen did not bind to merozoites when merozoites and supernatant antigens were from different strains unless proteinase inhibitors were present. Moreover, erythrocytes coated with supernatant antigens from the Camp or FCR-3 strain were invaded normally by merozoites of the homologous strain but were partially resistant to invasion by merozoites of the heterologous strain. The 175K antigen may be a receptor acting as a "bridge" between erythrocytes and merozoites.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Eritrócitos
/
Antígenos de Protozoários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article