Acetylcholine stimulates phosphatidylinositol turnover at nicotinic receptors of cultured myotubes.
FEBS Lett
; 190(1): 161-4, 1985 Oct 07.
Article
em En
| MEDLINE
| ID: mdl-4043395
ABSTRACT
Acetylcholine treatment of [3H]inositol pre-labelled cultured chick embryo myotubes results in the stimulation of phosphatidylinositol breakdown, as shown by the measurement of inositol-1-phosphate accumulating in the presence of lithium. The described effect is dependent on agonist concentration and incubation time, and is inhibited by tubocurarine and alpha-bungarotoxin. The activation of phosphatidylinositol breakdown by acetylcholine at extrajunctional nicotinic receptors is likely to be involved in the modulation of the functional activity of the receptor.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilinositóis
/
Acetilcolina
/
Receptores Nicotínicos
/
Músculos
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1985
Tipo de documento:
Article