Characterization of a unique muscle cell line.
J Cell Biol
; 61(2): 398-413, 1974 May.
Article
em En
| MEDLINE
| ID: mdl-4363958
ABSTRACT
A clonal cell line derived from a mouse neoplasm is described which shares many properties with smooth muscle. The cells have electrically excitable membranes capable of generating overshooting action potentials, and they contract both spontaneously and with electrical stimulation. They respond to the iontophoretic application of acetylcholine with a depolarizing response, and to norepinephrine with a hyperpolarizing response. Electron microscopy reveals that the cells have a morphology similar in many, but not all, respects to that of smooth muscle cells in vivo. The cells secrete soluble collagen-like molecules in addition to several proteins of undefined function. Finally, there is an increase in the specific activities of creatine phosphokinase and myokinase associated with increased cell density and the cessation of cell division.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linhagem Celular
/
Neoplasias de Tecido Muscular
Limite:
Animals
Idioma:
En
Revista:
J Cell Biol
Ano de publicação:
1974
Tipo de documento:
Article