Activation of latent Graves' disease in children. Review of possible psychosomatic mechanisms.
Clin Pediatr (Phila)
; 19(3): 160-3, 1980 Mar.
Article
em En
| MEDLINE
| ID: mdl-6244127
ABSTRACT
In some children, psychological events have appeared to be important in the triggering of Graves' disease. This report examines the case histories of three children in whom the appearance of symptomatology of Graves' disease was associated with depression following the death of a loved one. An analysis of neuroendocrine and immunologie pathways suggests that depression, set off by bereavement, causes low levels of norepinephrine in the brain. The latter in turn may mediate an increase in ACTH and cortisol, leading to reductions in immune surveillance and resultant production of thyroid-stimulating immunoglobulins, hence the development of Graves' disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicofisiológicos
/
Estresse Psicológico
/
Doença de Graves
/
Depressão
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Pediatr (Phila)
Ano de publicação:
1980
Tipo de documento:
Article