gamma 1-Melanotropin-like immunoreactivity in bovine and human adrenocorticotropin-producing tissues.
J Clin Endocrinol Metab
; 56(5): 1080-3, 1983 May.
Article
em En
| MEDLINE
| ID: mdl-6300175
ABSTRACT
gamma 1 MSH-like immunoreactivity in bovine pituitary glands, hypothalami, human pituitary glands, ectopic ACTH-producing tumors, and human gastric antral mucosa was investigated using a newly developed RIA for gamma 1 MSH. The minimum detectable quantity of gamma 1 MSH was 3 pg/tube, and the antibody did not cross-react with gamma 2 MSH, gamma 3 MSH, alpha MSH, beta MSH, ACTH, beta-lipotropin, or beta-endorphin. Bovine anterior pituitary, intermediate-posterior pituitary, and hypothalamus contained more than two molecular weight forms of gamma 1 MSH-like immunoreactivities. On the other hand, gamma 1 MSH-like immunoreactivity was not detected in human pituitary glands or human gastric antral mucosa, but was detected in one of seven ectopic ACTH-producing tumors. These results suggest a limited processing of the ACTH-beta-lipotropin precursor to gamma 1 MSH in human tissues, although a rapid degradation of gamma 1 MSH could not be ruled out completely.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipófise
/
Hormônios Estimuladores de Melanócitos
/
Hormônio Adrenocorticotrópico
/
Mucosa Gástrica
/
Hipotálamo
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
1983
Tipo de documento:
Article