Effect of decreased feed intake on serum and pancreatic alpha-amylase of broiler chickens.

ABSTRACT

Removal of feed from 20-day-old broiler chicks for 24 hours caused serum and pancreatic alpha-amylase activities to increase almost twofold. A 24-hour feeding period following feed removal caused a reduction in serum alpha-amylase to basal levels and a sixfold reduction in pancreatic alpha-amylase activity. Serum alpha-amylase levels remained elevated after long-term feed restriction in adult broilers compared with levels in full-fed controls. Reduction in feed intake in chicks caused by coccidial infections also resulted in increased serum alpha-amylase. In all cases, the degree of change in serum alpha-amylase corresponded inversely to feed intake. It is proposed that the pancreas synthesizes a specific quantity of alpha-amylase, which does not change even under conditions of extended underconsumption of feed. The rate of alpha-amylase secretion is determined, at least indirectly, by the rate of carbohydrate metabolism, and the remainder of the enzyme is stored in the pancreatic cells. A small percentage of the stored enzyme diffuses into the blood and thus directly reflects increased secretion or accumulation of alpha-amylase in the pancreas in response to conditions of carbohydrate utilization.