Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor.
Science
; 222(4626): 935-7, 1983 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-6415815
ABSTRACT
Intracisternal injection of ovine corticotropin-releasing factor (CRF) into the pylorus-ligated rat or the rat with gastric fistula resulted in a dose-dependent inhibition of gastric secretion stimulated with pentagastrin or thyrotropin-releasing hormone. When injected into the lateral hypothalamus--but not when injected into the cerebral cortex--CRF suppressed pentagastrin-stimulated acid secretion. The inhibitory effect of CRF was blocked by vagotomy and adrenalectomy but not by hypophysectomy or naloxone treatment. These results indicate that CRF acts within the brain to inhibit gastric acid secretion through vagal and adrenal mechanisms and not through hypophysiotropic effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Hormônio Liberador da Corticotropina
/
Ácido Gástrico
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article