Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion.
Science
; 210(4476): 1369-71, 1980 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-6449080
ABSTRACT
Monoamine oxidase activity was higher in the cerebral cortex and basal ganglia of patients dying from Huntington's disease than in controls. Enzyme kinetics and multiple substrate studies indicated that the increased activity was due to elevated concentrations of monoamine oxidase type B. Concentrations of homovanillic acid were increased in the cerebral cortex but not in the basal ganglia of brains of patients with Huntington's disease. These changes may represent a primary aminergic lesion that could underlie some of the mental symptoms of this disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilacetatos
/
Gânglios da Base
/
Córtex Cerebral
/
Doença de Huntington
/
Ácido Homovanílico
/
Monoaminoxidase
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
1980
Tipo de documento:
Article