The phosphorylase kinase activity of hearts from phosphorylase kinase-deficient mice.
Biochem Genet
; 21(7-8): 781-6, 1983 Aug.
Article
em En
| MEDLINE
| ID: mdl-6626146
ABSTRACT
In an assay measuring radioactive incorporation from gamma--P32P]ATP into phosphorylase b, cardiac muscle extracts from mice with the phosphorylase kinase deficiency mutation showed significant, calcium-dependent phosphorylase kinase activity that was 10 to 15% of that of Swiss mice, the control strain. Isoproterenol stimulated significant phosphorylase a accumulation in both isolated atria and right ventricular strips of phosphorylase kinase-deficient mice, and the drug-stimulated increases in phosphorylase a activity the the contractile responses of right ventricular strips were similar in Swiss and phosphorylase kinase/deficient mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilase Quinase
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Biochem Genet
Ano de publicação:
1983
Tipo de documento:
Article