Rapid GC method for quantitation of nifedipine in serum using electron capture detection.
J Chromatogr Sci
; 21(9): 415-9, 1983 Sep.
Article
em En
| MEDLINE
| ID: mdl-6630401
ABSTRACT
For studying the pharmacokinetics of nifedipine after single doses, a rapid, specific, reliable gas chromatographic assay procedure for nifedipine in serum is developed. Using a single-step solvent extraction or a bonded-phase column extraction and electron capture detection, an assay sensitivity of 10 to 25 ng/ml can be achieved using 0.25 ml of serum. The assay quantitates intact nifedipine and separates it reproducibly from its nitro- and nitrosopyridine derivatives.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nifedipino
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
J Chromatogr Sci
Ano de publicação:
1983
Tipo de documento:
Article