Hydrolysis of cyclomethasone by the human lung.
Int J Clin Pharmacol Res
; 3(1): 17-20, 1983.
Article
em En
| MEDLINE
| ID: mdl-6679503
ABSTRACT
The hydrolysis rate of 9-chloro-11 beta, 17a-dihydroxy-16 beta-methyl-21-(1'4'N-acetyltransaminomethyl- cyclohexancarbonyloxy) pregna-1,4-diene-3,20-dione (cyclomethasone) and of beclomethasone 17,21-dipropionate was studied on human lung slices. Cyclomethasone is hydrolysed more slowly than beclomethasone 17,21-dipropionate. This difference may be ascribed to a different affinity and/or activity of the tissue esterases towards the two substrates or to a different transport rate in the sites of the esterase activity. Since the steroid moiety is the same for both molecules studied it appears that the hydrolysis and/or the transport rate of the esterified steroids depends on the chemical properties of the substituent at C-21.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pulmão
Limite:
Humans
Idioma:
En
Revista:
Int J Clin Pharmacol Res
Ano de publicação:
1983
Tipo de documento:
Article