[Biotransformation and pharmacokinetics of beta-methyl-(1,1'-biphenyl)-4-propanenitrile (LU 20884) in rats. Studies on pharmacokinetics]. / Biotransformation und Pharmakokinetik von beta-Methyl-[1,1'-biphenyl]-4-propannitril (LU 20884) an Ratten. Untersuchungen zur Pharmakokinetik.

ABSTRACT

After oral application in Wistar rats the pharmacokinetic properties of beta-methyl[1,1'-biphenyl]-4-propanenitrile (LU 20884) were investigated. The compound is extensively absorbed, a maximum amount of 8.9% being eliminated as unchanged drug. The half-life in plasma is 22.7 h; the highest concentration in plasma is reached after 6.85 h. The maximum of the primary product is achieved after 4 h which substantiates its intensive and fast rate of metabolism. The distribution of LU 20884 is to be seen in the whole organism. An enrichment of activity is to be found in liver and kidney. The lowest concentration can be detected in brain. The elimination takes place almost equally in urine (44.7%) and feces (41.3%). The total excretion of the administered activity is 86.0% after 96 h; 1.8% of the activity still remains in the organism.