Theoretical basis for the detection of general-base catalysis in the presence of predominating hydroxide catalysis.
J Pharm Sci
; 73(6): 724-7, 1984 Jun.
Article
em En
| MEDLINE
| ID: mdl-6737254
ABSTRACT
The detection of general-base catalysis in the presence of predominating specific-base catalysis in aqueous buffer solutions is examined for various relationships between k0cat and k0OH, the bimolecular rate constants for general-base and hydroxide-ion attack. The three experimental variables that affect the detection of buffer-base catalysis are the type of buffer, conjugate-acid concentration, and ionic strength. Various buffers used in pharmaceutical kinetic studies are considered, and it is concluded that buffers with high Ka values favor detection. Additionally, high conjugate-acid concentrations and ionic strengths appear to optimize the detection of general-base catalysis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catálise
/
Álcalis
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1984
Tipo de documento:
Article