Anatomical distribution of call antigen expressing cells in normal lymphatic tissue and in lymphomas.
Leuk Res
; 6(6): 761-7, 1982.
Article
em En
| MEDLINE
| ID: mdl-6961269
ABSTRACT
Anatomical distribution of common acute lymphoblastic leukemia antigen (CALLA) was studied in lymphomas as well as in normal lymphatic organs using the monoclonal antibody VIL-A1. Twelve lymphomas were labelled by VIL-A1. Three of the 12 tumours also had T-cell marker, six lymphomas also showed immunoglobulin staining and only three tumours were pure CALLA lymphomas. Tonsils showed a distinct CALLA labelling of many germinal centre cells and of singular cells in interfollicular T-cell regions. Children's thymuses showed rare distinctly labelled cells in the cortex and medulla and slightly more cortical cells stained faintly by VIL-A1. Foetal thymuses of about the twelfth week of gestation contained many heavily labelled cells. The findings are discussed as evidence for the presence of CALLA on immature B as well as T lymphocytes. They favour the idea of CALLA as a common lymphocyte differentiation antigen although other possibilities of interpretation are also discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Linfoide
/
Sistema Linfático
/
Linfoma
/
Antígenos de Neoplasias
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Leuk Res
Ano de publicação:
1982
Tipo de documento:
Article