[Modalities of production and immunity conferred by an inactivated rabies vaccine originating from cell culture]. / Modalités de production et immunité conferée par un vaccin antirabique inactivé provenant de culture cellulaire.

ABSTRACT

Further to guidelines advised by the World Health Organization, an inactivated Rabies vaccine was prepared from virus propagated on cell culture. This vaccine is presented either in the freeze-dried form or in the liquid form together with an immunity adjuvant. The specific and nonspecific immunity of the vaccine is excellent. The potency, tested in laboratory animals and in species for which the vaccine is intended, satisfies recommendations published by the W.H.O. The immunity persistence, evaluated by the titration of serum antibodies and by challenge with a pathogenic virus, proves to be excellent 3 years following primovaccination. Finally, the stability of this vaccine is an interesting factor for its application, especially in the form of a combined vaccine.