An in vitro study on the toxoplasmacidal activity of lonomycin A in host cells.
J Antibiot (Tokyo)
; 34(2): 218-23, 1981 Feb.
Article
em En
| MEDLINE
| ID: mdl-7298512
ABSTRACT
Lonomycin A at various concentrations was tested for its inhibitory effect on Toxoplasma multiplication in host cells cultured in vitro. Results indicate that lonomycin A at a concentration of 0.01 micrograms per ml in TC-199 medium demonstrated a high degree of antitoxoplasma activity with complete inhibition of Toxoplasma multiplication in the host cells. Lymphokines, a supernatant produced from spleen cells of mice infected chronically with Toxoplasma gondii, inhibited Toxoplasma multiplication in mice macrophage and kidney cell monolayers. However, lonomycin A inhibited completely Toxoplasma multiplication in non-specific cells, i.e. not only in mice macrophages and kidney cells but also in cells of human and other animal species.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Antibacterianos
/
Nigericina
/
Antiprotozoários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1981
Tipo de documento:
Article