Anion transport function of mouse erythroid band 3 protein (AE1) does not require acylation of cysteine residue 861.
Biochim Biophys Acta
; 1194(2): 341-4, 1994 Sep 14.
Article
em En
| MEDLINE
| ID: mdl-7522566
ABSTRACT
Cys-861 of mouse band 3 is equivalent to Cys-843 of human band 3, the only acylated cysteine residue in the anion exchanger AE1 of the red blood cell (Hamasaki et al. (1992) Progress Cell Res. 2, 65-71). Mutation of Cys-861 to serine or methionine caused no significant changes of band 3-mediated anion exchange as measured after expression of the appropriate cRNAs in Xenopus oocytes. Susceptibility to inhibition of transport by 4,4'-dinitrostilbene-2,2'-disulfonate and PCMBS was not affected. We conclude that palmitoylation is not an absolute requirement for the successful execution the anion transport function by the hydrophobic domain of band 3 in the plasma membrane.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína 1 de Troca de Ânion do Eritrócito
/
Cisteína
/
Ânions
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha