Plasma neurotransmitters, blood pressure, and heart rate during supine resting, orthostasis, and moderate exercise in dysthymic depressed patients.
Biol Psychiatry
; 37(12): 884-91, 1995 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-7548463
ABSTRACT
Dysthymic depressed patients showed platelet-serotonin (pS) + plasma-free serotonin values greater than normal as well as plasma noradrenaline values lower than normal during supine resting period (0'). Conversely, no significant differences were observed in the 0' values of any other of the measured parameters systolic, diastolic and differential blood pressure (SBP, DBP, DP), heart rate (HR), adrenaline (Ad), dopamine (DA), cortisol, and platelet aggregability between patients and controls. Although patients showed then normal DP reduction at orthostasis (1'), this was not prevented by atropine as it does in controls. Patients but not normals showed significant rises of DBP at orthostasis and exercise (5') periods, which were positively correlated with NA rises. On the contrary, the abnormally raised resting fS values registered in patients showed progressive and significant reductions throughout the test that were negatively correlated with DBP-NA values. Adrenaline did not show the normal 5'-fS peak. The above findings suggest that dysthymics show hypoactivity of the two branches of the sympathetic system (neural + adrenal) along with hyperparasympathetic activity. Furthermore, their low NA + high pS values contrast with the high NA + low pS registered in major depressed subjects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Descanso
/
Pressão Sanguínea
/
Monoaminas Biogênicas
/
Exercício Físico
/
Transtorno Depressivo
/
Frequência Cardíaca
/
Hipotensão Ortostática
Limite:
Adolescent
/
Adult
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
1995
Tipo de documento:
Article