Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats.
Dig Dis Sci
; 38(4): 653-9, 1993 Apr.
Article
em En
| MEDLINE
| ID: mdl-7681747
ABSTRACT
When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release against CCK-8 in the pancreatic acini decreased when plasma CCK level was high. These changes in pancreatic growth and pancreatic enzyme secretion caused by PBD were completely inhibited by the CCK-receptor antagonist loxiglumide. From these results, intrinsic CCK was considered to play an important role in both pancreatic enzyme synthesis and proliferation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Proglumida
/
Colecistocinina
/
Procedimentos Cirúrgicos do Sistema Biliar
Limite:
Animals
Idioma:
En
Revista:
Dig Dis Sci
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Japão