Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor.
Biochim Biophys Acta
; 1224(3): 454-8, 1994 Dec 30.
Article
em En
| MEDLINE
| ID: mdl-7803503
ABSTRACT
We investigated endothelin-1 (ET-1) receptor expression on normal human keratinocytes (HK). We show that HK express the ETB receptor isoform and respond to ET-1 with a 2.7-fold increase in intracellular free calcium. HK did not respond to ET-1 with increased proliferation; however, 30 nM ET-1 caused a 51.7% decrease in ET-1 accumulation in HK-conditioned medium. We propose that HK ET-1 receptors function in autocrine regulation of ET-1 secretion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queratinócitos
/
Endotelinas
/
Receptores de Endotelina
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1994
Tipo de documento:
Article