Calyculin A blocks bovine chromaffin cell calcium channels independently of phosphatase inhibition.
Neurosci Lett
; 178(1): 55-8, 1994 Aug 29.
Article
em En
| MEDLINE
| ID: mdl-7816340
ABSTRACT
The specific phosphatase inhibitor, Calyculin-A (CL-A), decreases high-K stimulated catecholamine secretion in bovine chromaffin cells. This effect can be split into two components one needs long exposures to the drug to be elicited, and is sensitive to the protein kinase-inhibitor K252a; the other is observed after short incubations of CL-A, and is insensitive to K252a. Here we report that the latter component is due to an external block, by CL-A, of chromaffin cell calcium channels in a voltage-dependent, reversible and phosphorylation-independent manner.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxazóis
/
Bloqueadores dos Canais de Cálcio
/
Canais de Cálcio
/
Medula Suprarrenal
/
Fosfoproteínas Fosfatases
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Espanha