Corticotropin release inhibiting factor is encoded within prepro-TRH.
Endocrinology
; 136(4): 1813-6, 1995 Apr.
Article
em En
| MEDLINE
| ID: mdl-7895696
ABSTRACT
Corticotropin synthesis and secretion is under negative feedback regulation by glucocorticoids. In addition a hypothalamic factor inhibiting ACTH synthesis and secretion, named corticotropin release inhibiting factor (CRIF), has been postulated but not identified. Here we report that transient transfection of a rat prepro-TRH cDNA into the mouse anterior pituitary tumor cell line AtT-20 inhibits the synthesis and secretion of both basal and CRH-stimulated ACTH. Thus, CRIF appears to be encoded by the same precursor as TRH, suggesting a coordinated regulation of pituitary-adrenal and pituitary-thyroid functions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adeno-Hipófise
/
Precursores de Proteínas
/
Hormônio Liberador de Tireotropina
/
Hormônio Adrenocorticotrópico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1995
Tipo de documento:
Article