Autoantibodies against ganglioside GM3 represent a portion of anti-lymphocyte antibodies in AIDS patients.
Scand J Immunol
; 40(1): 77-82, 1994 Jul.
Article
em En
| MEDLINE
| ID: mdl-7913247
ABSTRACT
In this study we analysed the relationship between anti-lymphocytic ganglioside antibodies and anti-lymphocyte antibodies in AIDS patients. Anti-lymphocytic ganglioside antibodies were detected by thin layer chromatography (TLC) immunostaining; three colour flow cytometry was used to analyse circulating antibodies against different lymphocyte subsets. Anti-lymphocytic ganglioside antibodies were detected in 23 out of 49 AIDS patients sera (46.9%). All positive sera reacted selectively with the GM3 comigrating band from AIDS lymphocytes. Twenty two out of the 23 anti-lymphocytic GM3 positive sera also had antibodies against CD4+T cells, versus 17/26 anti-GM3 negative. Furthermore, patients with lymphocytic GM3 antibodies showed a significantly higher antibody reactivity against CD4+ T cells than patients in which these antibodies were not detected. The absorption tests revealed that preincubation of positive sera with GM3 was followed by a decrease in the reaction with target lymphocytes. These findings suggest that anti-GM3 antibodies are a portion, but not the majority, of antibodies reacting with CD4+ T cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Linfócitos T CD4-Positivos
/
Síndrome da Imunodeficiência Adquirida
/
Gangliosídeo G(M3)
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Scand J Immunol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Alemanha