The molecular basis for dominant yellow agouti coat color mutations.
Bioessays
; 16(10): 705-7, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7980472
ABSTRACT
Agouti expression during the middle portion of the mouse hair growth cycle induces melanocytes to synthesize yellow instead of black pigment, generating black hairs with a yellow band. Dominant agouti alleles increase the amount of yellow pigment in the coat and are associated with pleiotropic effects including obesity, diabetes and increased tumor susceptibility. Four dominant agouti alleles (Aiapy, Aiy, and Avy) were recently shown to result from insertions that cause ubiquitous expression of chimeric transcripts encoding a wild-type agouti protein(1,2). Three insertions were identified as intracisternal A-particles, which helps explain the variable coat colors and parental imprinting effects associated with some dominant agouti alleles.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cor de Cabelo
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Genes Dominantes
/
Camundongos Mutantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Bioessays
Assunto da revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Ano de publicação:
1994
Tipo de documento:
Article