Deficient T-cell responses in non-responders to hepatitis B vaccination: absence of TH1 cytokine production.
Immunol Lett
; 39(2): 163-8, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8013962
ABSTRACT
The inability to mount a protective level (> or = 10 IU/l) of hepatitis B surface antigen (HBsAg)-specific antibodies after vaccination is presumably the consequence of a defect in the cellular immune regulation. We compared the in vitro immune responses of peripheral blood mononuclear cells (PBMC) from high, intermediate and non-responders, after stimulation with recombinant HBsAg. The absence of a proliferative response in non-responders was not reversed by removal of CD8+ T cells, indicating that HBsAg-specific CD8+ T-cell-induced suppression was not the underlying cause of non-responsiveness. Non-responders did not produce cytokines after HBsAg stimulation. High responders displayed a typical Th1-like profile since their PBMC produced interleukin-2 (IL-2) and gamma-interferon (IFN gamma) and no detectable IL-4 or IL-5 upon stimulation with HBsAg.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Citocinas
/
Vacinas contra Hepatite B
/
Linfócitos T Reguladores
/
Linfócitos T Auxiliares-Indutores
/
Hepatite B
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Bélgica