Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persistence.
C R Acad Sci III
; 316(7): 682-7, 1993 Jul.
Article
em En
| MEDLINE
| ID: mdl-8019890
ABSTRACT
Confocal laser scanning microscopy and immunofluorescence were used to detect gentamicin at the single cell level in the sensory cells of the guinea-pig hearing organ after a chronic systemic treatment. Gentamicin uptake by the hair cells precedes largely the manifestation of hearing impairment. We demonstrate that for a non-ototoxic treatment the captured gentamicin is eliminated in two phases one rapid and one slow with approximate half-life of 2 days and 5-6 months, respectively. These novel observations should be of primary importance for new rational approaches to both the mechanism of ototoxicity and therapeutic strategies for the treatment of infectious diseases requiring the aminoglycoside antibiotics.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Órgão Espiral
/
Gentamicinas
/
Células Ciliadas Auditivas
Limite:
Animals
Idioma:
En
Revista:
C R Acad Sci III
Assunto da revista:
BIOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
França