Alteration of membrane transductive mechanisms induced by ethanol in human lymphocyte cultures.
Cell Signal
; 5(2): 139-43, 1993 Mar.
Article
em En
| MEDLINE
| ID: mdl-8388700
ABSTRACT
Ethanol, in millimolar concentrations, significantly modifies different transductive systems in human lymphocyte cultures. In particular, the presence of alcohol in the medium more than doubles the [Ca2+]i (from 70-90 to 200-250 nM), increasing Ca2+ fluxes from outside, and inhibits the active transport carried out by the calcium pump. The Ca2+ release from intracellular stores is not involved because 10 mM EGTA in the medium completely abolished the rise of [Ca2+]i. Since IP3 levels and cAMP concentrations are also involved in ethanol events (although with opposite effects), it seems that the alcohol may have a specific target on cell membranes (G-proteins) which influence many transductive pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Transdução de Sinais
/
Cálcio
/
ATPases Transportadoras de Cálcio
/
Proteínas de Ligação ao GTP
/
Etanol
Limite:
Humans
Idioma:
En
Revista:
Cell Signal
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Itália