Adaptive evolution of human immunodeficiency virus-type 1 during the natural course of infection.
Science
; 272(5261): 537-42, 1996 Apr 26.
Article
em En
| MEDLINE
| ID: mdl-8614801
ABSTRACT
The rate of progression to disease varies considerably among individuals infected with human immunodeficiency virus-type 1 (HIV-1). Analyses of semiannual blood samples obtained from six infected men showed that a rapid rate of CD4 T cell loss was associated with relative evolutionary stasis of the HIV-1 quasispecies virus population. More moderate rates of CD4 T cell loss correlated with genetic evolution within three of four subjects. Consistent with selection by the immune constraints of these subjects, amino acid changes were apparent within the appropriate epitopes of human leukocyte antigen class I-restricted cytotoxic T lymphocytes. Thus, the evolutionary dynamics exhibited by the HIV-1 quasispecies virus populations under natural selection are compatible with adaptive evolution.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Antigênica
/
Linfócitos T Citotóxicos
/
Infecções por HIV
/
HIV-1
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos