Virus encoding an encephalitogenic peptide protects mice from experimental allergic encephalomyelitis.
J Neuroimmunol
; 64(2): 163-73, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8632058
ABSTRACT
The association of viral infections with autoimmune central nervous system (CNS) diseases such as post-infectious encephalomyelitis and possibly multiple sclerosis (MS) prompted the investigation to understand how virus infection could modulate autoimmune responses. Recombinant vaccinia viruses encoding an encephalitogenic portion of myelin basic protein (MBP) were evaluated in an animal model for human demyelinating disease, experimental allergic encephalomyelitis (EAE). We have determined that mice vaccinated with recombinant viruses encoding an encephalitogenic region of MBP were protected from EAE. In vivo depletion of CD8+ T cells did not abrogate this protection, suggesting lack of regulation by this cell type. These studies demonstrate that virus infection may be a means to modulated immune responsiveness to CNS disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Doenças Autoimunes
/
Vaccinia virus
/
Proteína Básica da Mielina
/
Encefalomielite Autoimune Experimental
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Estados Unidos