Comparative clinical studies of ototoxicity and nephrotoxicity of amikacin and gentamicin.
Am J Med
; 62(6): 919-23, 1977 Jun.
Article
em En
| MEDLINE
| ID: mdl-868906
ABSTRACT
A comparative study of the oto- and nephrotoxicity of amikacin and gentamicin was carried out prospectively. Twenty-six gentamicin-treated patients and 27 amikacin-treated patients were monitored for changes in auditory and renal function during and after therapy. Thirteen of those treated with gentamicin and 20 of those treated with amikacin underwent vestibular caloric testing which could be evaluated for evidence of toxicity. In four (15.4%) of the gentamicin-treated patients, nephrotoxicity developed; no such toxicity was seen in the amikacin-treated patients. This difference may have been due to a fortuitously higher incidence of pretreatment renal impairment in the gentamicin-treated group. In two gentamicin-treated patients (7.7%), ototoxicity developed (one auditory, one vestibular), and in two amikacin-treated patients (7.4%), auditory toxicity developed. Statistical analysis of oto- and nephrotoxicity and their risk factors was not attempted because of the small numbers of patients who could be evaluated. Additional patients are being studied.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amicacina
/
Gentamicinas
/
Canamicina
/
Audição
/
Rim
Tipo de estudo:
Clinical_trials
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Med
Ano de publicação:
1977
Tipo de documento:
Article