Urtica dioica agglutinin, a V beta 8.3-specific superantigen, prevents the development of the systemic lupus erythematosus-like pathology of MRL lpr/lpr mice.
Eur J Immunol
; 26(8): 1707-11, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-8765010
ABSTRACT
The V beta 8.3-specific superantigenic lectin Urtica dioica agglutinin (UDA) was used to delete the V beta 8.3+ T cells in MRL lpr/lpr mice. In contrast to the systemic lupus erythematosus-like pathology which progresses with age in the phosphate-buffered saline-injected MRL lpr/lpr controls, UDA-treated animals did not develop overt clinical signs of lupus and nephritis. The pathogenic T cell clones thus reside within the V beta 8.3+ T cell population, which includes an expanded T cell clone described previously. Finally, UDA alters the production of autoantibodies in a sex-dependent manner.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T alfa-beta
/
Superantígenos
/
Lectinas de Plantas
/
Lectinas
/
Lúpus Eritematoso Sistêmico
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
França